Fiche publication
Date publication
janvier 1999
Journal
Revue de laryngologie - otologie - rhinologie
Auteurs
Membres identifiés du Cancéropôle Est :
Pr DOLIVET Gilles
,
Dr GEOFFROIS Lionnel
,
Pr MERLIN Jean-Louis
Tous les auteurs :
Dolivet G, Colosetti P, Merlin JL, Depardieu C, Lapeyre M, Wattel E, Sarini J, Ton Van J, Geoffrois L, Lagarde P
Lien Pubmed
Résumé
The study of epidemiology and of the carcinogenesis in epidermoid carcinomas of the upper aerodigestive tract shows that their occurrence is not random. Tobacco abuse plays a major role, especially because of benzopyrene, mutagen of the P53 gene, however it is associated with many other potentiating factors: alcohol, metals, hydrocarbures, virus, food, climate, genetic fragility that create genetic lesions at the origin of carcinogenesis. The latter occurs as "field cancerization" with multiple alterations of the mucosa and general attack of the control systems of the differentiation, growth and cell apoptosis which usually protect the cell against the phenomena of carcinogenesis. The P53 protein gene, retinoid receptors as well as the system of detoxifying glutathion S transferase are modified at the very early stage of these diseases, these abnormalities can be logically related to epidemiological data. These data lead us therefore to imagine complementary specific reverting therapies of induced genetic abnormalities, through the reexpression of non mutated gene encoding P53 protein and the use of retinoid. These various modalities are reported hereafter.
Mots clés
Age Factors, Carcinoma, Squamous Cell, epidemiology, Esophageal Neoplasms, epidemiology, Genes, p53, genetics, Humans, Laryngeal Neoplasms, epidemiology, Pharyngeal Neoplasms, epidemiology, Proto-Oncogene Proteins, genetics, Retinoids, therapeutic use, Risk Factors
Référence
Rev Laryngol Otol Rhinol (Bord). 1999 ;120(1):5-12
