Counterbalancing anti-adhesive effects of Tenascin-C through fibronectin expression in endothelial cells.

Date publication

octobre 2017

Journal

Scientific reports

Auteurs

Membres identifiés du Cancéropôle Est :
Dr OREND Gertraud

Tous les auteurs :
Radwanska A, Grall D, Schaub S, Divonne SBF, Ciais D, Rekima S, Rupp T, Sudaka A, Orend G, Obberghen-Schilling EV

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/28986537

Résumé

Cellular fibronectin (FN) and tenascin-C (TNC) are prominent development- and disease-associated matrix components with pro- and anti-adhesive activity, respectively. Whereas both are present in the tumour vasculature, their functional interplay on vascular endothelial cells remains unclear. We have previously shown that basally-oriented deposition of a FN matrix restricts motility and promotes junctional stability in cultured endothelial cells and that this effect is tightly coupled to expression of FN. Here we report that TNC induces FN expression in endothelial cells. This effect counteracts the potent anti-adhesive activity of TNC and leads to the assembly of a dense highly-branched subendothelial matrix that enhances tubulogenic activity. These findings suggest that pro-angiogenic remodelling of the perivascular matrix may involve TNC-induced upregulation of FN in endothelial cells.

Référence

Sci Rep. 2017 Oct;7(1):12762