Tau protein as a possible marker of cerebrospinal fluid leakage in cerebrospinal fluid rhinorrhoea: A pilot study.

Fiche publication

Date publication

octobre 2017

Journal

Biochemia medica

Auteurs

Membres identifiés du Cancéropôle Est :
Pr LABROUSSE Marc , Pr RAMONT Laurent , Dr OUDART Jean-Baptiste

Tous les auteurs :
Oudart JB, Zucchini L, Maquart FX, Dubernard X, Labrousse M, Fiabane G, Quedreux A, Litre F, Ramont L

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/28900366

Résumé

The management of posttraumatic cerebrospinal fluid (CSF) rhinorrhoea remains a clinical challenge. Cerebrospinal fistula is a dural defect responsible for possible CSF leakage into the contiguous air-filled cavities located at the skull base. The risk of central nervous system infection in these conditions is severe and can be life threatening. Consequently, a specific CSF biomarker might be used in case of difficult diagnosis of CSF rhinorrhoea. CSF Tau protein is a neuronal protein, commonly assessed for diagnosis of Alzheimer Disease (AD). The aim of this study was to determine whether the Tau protein could be a relevant marker of CSF leakage.