Fiche publication
Date publication
mars 1992
Journal
The Journal of rheumatology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BRIANCON Serge
,
Pr GUILLEMIN Francis
Tous les auteurs :
Guillemin F, Briançon S, Pourel J
Lien Pubmed
Résumé
A hypothesis that the development of functional disability in rheumatoid arthritis (RA) would be more rapid at the beginning than in established disease was studied in a group of 82 patients with RA referred to the Rheumatology Unit of Nancy, France. The relationship between disease activity, articular destruction and functional disability indicated a significant interaction (moderating effect) of disease duration. Two different models are proposed to explain functional disability. A model for early RA (less than 5 years duration) includes biological activity, and a model for established disease (more than 5 years) includes disease duration, extraarticular lesions and radiographic damage. These models could be useful in designs of therapeutic trials.
Mots clés
Arthritis, Rheumatoid, physiopathology, Disability Evaluation, Female, Humans, Male, Middle Aged, Models, Biological, Regression Analysis
Référence
J. Rheumatol.. 1992 Mar;19(3):366-9
