The Nuclear Bile Acid Receptor FXR is a PKA- and FOXA2-Sensitive Activator of Fasting Hepatic Gluconeogenesis.

Fiche publication

Date publication

juillet 2018

Journal

Journal of hepatology

Auteurs

Membres identifiés du Cancéropôle Est :
Dr CIANFERANI Sarah

Tous les auteurs :
Ploton M, Mazuy C, Gheeraert C, Dubois V, Berthier A, Dubois-Chevalier J, Maréchal X, Bantubungi-Blum K, Diemer H, Cianférani S, Strub JM, Helleboid-Chapman A, Eeckhoute J, Staels B, Lefebvre P

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/29981427

Résumé

Embedded into a complex signaling network coordinating glucose uptake, usage and production, the nuclear bile acid receptor FXR is expressed in several glucose-processing organs including the liver which synthesizes, stores or mobilizes glucose according to the organism's needs. Dysregulated in type 2 diabetes, hepatic gluconeogenesis (GNG) is controlled through allosteric regulation of gluconeogenic enzymes and by glucagon/cAMP-dependent transcriptional regulatory pathways. Whether FXR positively or negatively regulates fasting hepatic gluconeogenesis is still debated.