Multilocus sequence typing of clinical Borreliella afzelii strains: population structure and differential ability to disseminate in humans.

Date publication

juin 2018

Journal

Parasites & vectors

Auteurs

Membres identifiés du Cancéropôle Est :
Pr LIPSKER Dan , Pr SAULEAU Erik-André

Tous les auteurs :
Gallais F, De Martino SJ, Sauleau EA, Hansmann Y, Lipsker D, Lenormand C, Talagrand-Reboul E, Boyer PH, Boulanger N, Jaulhac B, Schramm F

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/29954419

Résumé

Lyme borreliosis in humans results in a range of clinical manifestations, thought to be partly due to differences in the pathogenicity of the infecting strain. This study compared European human clinical strains of Borreliella afzelii (previously named Borrelia afzelii) using multilocus sequence typing (MLST) to determine their spatial distribution across Europe and to establish whether there are associations between B. afzelii genotypes and specific clinical manifestations of Lyme borreliosis. For this purpose, typing was performed on 63 strains, and data on a further 245 strains were accessed from the literature.

Mots clés

Borrelia, Borreliella, Borreliella afzelii, Lyme borreliosis, Multilocus sequence typing

Référence

Parasit Vectors. 2018 Jun 28;11(1):374