Fiche publication
Date publication
juin 2018
Journal
Revue des maladies respiratoires
Auteurs
Membres identifiés du Cancéropôle Est :
Pr MARIE Pierre-Yves
Tous les auteurs :
Chaouat A, Cherifi A, Sitbon O, Girerd N, Zysman M, Faure M, Mandry D, Mercy M, Guillaumot A, Fay R, Marie PY, Chabot F
Lien Pubmed
Résumé
Haemodynamic follow up in pulmonary arterial hypertension (PAH) is currently based on right heart catheterisation (RHC). The primary objective of the EVITA study is to compare the use of cardiac magnetic resonance imaging (cMRI) with RHC in the identification of an unfavourable hemodynamic status. The secondary objectives are to determine the role of cMRI in the follow up process. Patients will undergo at diagnosis and at follow up visits both RHC and cMRI. Patients will be followed and treated according to the current guidelines. The primary endpoint will be an unfavourable haemodynamic status defined by cardiac index<2.5L/min/m or a right atrial pressure≥8mm Hg measured with RHC compared with a cardiac index<2.5L/min/m or right ventricle ejection fraction<35% or an absolute decrease of 10% from the previous measurement with cMRI. Exact values of sensitivity, specificity and 95% confidence intervals will be computed. A population of 180 subjects will have a power of 90% with an α risk of 5%. Univariate and multivariate Cox analysis will allow answering to the secondary objectives. We expect to demonstrate that cMRI could be partly used instead of RHC in the follow up of patients with PAH.
Mots clés
Cathétérisme cardiaque droit, Hypertension pulmonaire, Imagerie par résonance magnétique nucléaire, Magnetic resonance imaging, Pulmonary hypertension, Right heart catheterisation
Référence
Rev Mal Respir. 2018 Jun 23;:
