Circulating levels of 3-hydroxymyristate, a direct quantification of endotoxemia in non-infected cirrhotic patients.

Date publication

juin 2018

Journal

Liver international : official journal of the International Association for the Study of the Liver

Auteurs

Membres identifiés du Cancéropôle Est :
Pr DI MARTINO Vincent , Dr LAGROST Laurent , Dr PAIS DE BARROS Jean-Paul , Mme LAHEURTE Caroline

Tous les auteurs :
Weil D, Pais de Barros JP, Mourey G, Laheurte C, Cypriani B, Badet N, Delabrousse E, Grandclément E, Di Martino V, Saas P, Lagrost L, Thévenot T

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/29931819

Résumé

The quantification of lipopolysaccharide (LPS) in biological fluids is challenging. We aimed to measure plasma LPS concentration using a new method of direct quantification of 3-hydroxymyristate (3-HM), a lipid component of LPS, and to evaluate correlations between 3-HM and markers of liver function, endothelial activation, portal hypertension and enterocyte damage.

Mots clés

3-hydroxymyristate, bacterial translocation, cirrhosis, endotoxaemia, lipopolysaccharide, portal hypertension

Référence

Liver Int.. 2018 Jun 22;: