β-Cyclodextrin-functionalized Chitosan/Alginate Compact PolyElectrolyte Complexes (CoPECs) as Functional Biomaterials with Anti-Inflammatory Properties.

Fiche publication

Date publication

août 2018

Journal

ACS applied materials & interfaces

Auteurs

Membres identifiés du Cancéropôle Est :
Pr FOURNEL Sylvie , Dr FRISCH Benoit , Dr LAVALLE Philippe , Pr SCHAAF Pierre

Tous les auteurs :
Hardy A, Seguin C, Brion A, Lavalle P, Schaaf P, Fournel S, Bourel-Bonnet L, Frisch B, De Giorgi DM

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/30107127

Résumé

Nowadays, the need for therapeutic biomaterials displaying anti-inflammatory properties to fight against inflammation-related diseases is continuously increasing. Compact PolyElectrolyte Complexes (CoPECs) represent a new class of materials obtained by ultracentrifugation of a polyanion/polycation complexes suspension in the presence of salt. Here, a non-cytotoxic β-cyclodextrin-functionalized chitosan/alginate CoPEC was formulated, characterized and described as a promising drug carrier displaying an intrinsic anti-inflammatory property. This new material was successfully formed and due to the presence of cyclodextrins, it was able to trap and release hydrophobic drugs such as Piroxicam used as model drug. The intrinsic anti-inflammatory activity of this CoPEC was analyzed in vitro using murine macrophages in the presence of LipoPolySaccharide (LPS) endotoxin. In this model, it was shown that CoPEC inhibited LPS-induced TNF-α and NO release and moderated the differentiation of LPS-activated macrophages. Over time, this kind of bioactive biomaterial could constitute a new family of delivery systems and expand the list of therapeutic tools available to target inflammatory chronic diseases such as arthritis or Crohn's disease.