Physiological Whole-Brain Distribution of [F]FDOPA Uptake Index in Relation to Age and Gender: Results from a Voxel-Based Semi-quantitative Analysis.

Fiche publication

Date publication

août 2018

Journal

Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging

Auteurs

Membres identifiés du Cancéropôle Est :
Pr MARIE Pierre-Yves

Tous les auteurs :
Toch SR, Poussier S, Micard E, Bertaux M, Van Der Gucht A, Chevalier E, Marie PY, Guedj E, Verger A

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/30073569

Résumé

6-[F]fluoro-L-DOPA ([F]FDOPA), a positron emission tomography (PET) amino-acid tracer of brain decarboxylase activity, is used to assess the brain dopaminergic system. Using a voxel-based semi-quantitative analysis, this study aimed to determine whether a current brain uptake index of [F]FDOPA, expressed relative to the occipital background level, varies according to age and gender.