Stable Isotope-Labelled Morphine to Study in vivo Central and Peripheral Morphine Glucuronidation and Brain Transport in Tolerant Mice.

Date publication

juillet 2018

Journal

British journal of pharmacology

Auteurs

Membres identifiés du Cancéropôle Est :
Dr CIANFERANI Sarah , Dr VAN DORSSELAER Alain , Dr GOUMON Yannick , Pr POISBEAU Pierrick

Tous les auteurs :
Weinsanto I, Laux-Biehlmann A, Mouheiche J, Maduna T, Delalande F, Chavant V, Gabel F, Darbon P, Charlet A, Poisbeau P, Lamshöft M, Van Dorsselaer A, Cianferani S, Parat MO, Goumon Y

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/30051501

Résumé

Chronic administration of medication can have an important impact on metabolic enzymes leading to physiological adaptations. Morphine metabolism in the liver has been extensively studied following acute morphine treatment but morphine metabolic processes in the central nervous system are poorly characterised. Long-term morphine treatment is limited by the development of tolerance, resulting in a decrease of its analgesic effect. Whether or not morphine analgesic tolerance affects in vivo brain morphine metabolism and blood-brain barrier (BBB) permeability remains a major pending question. Thus, our aim was to characterise the in vivo metabolism and BBB permeability of morphine after long-term treatment at both central and peripheral levels.

Référence

Br. J. Pharmacol.. 2018 Jul 26;: