Absence of correlation between radiation-induced CD8 T-lymphocyte apoptosis and sequelae in patients with prostate cancer accidentally overexposed to radiation.

Date publication

août 2018

Journal

Oncotarget

Auteurs

Membres identifiés du Cancéropôle Est :
Pr HARLE Alexandre , Pr MERLIN Jean-Louis , Pr PEIFFERT Didier

Tous les auteurs :
Vogin G, Merlin JL, Rousseau A, Peiffert D, Harlé A, Husson M, Hajj LE, Levitchi M, Simon T, Simon JM

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/30220974

Résumé

454 patients with prostate adenocarcinoma were accidentally overexposed to radiation in Epinal hospital, France, between August 1999 and January 2007. We aimed toevaluate whether radiation-induced CD4 or CD8 T-lymphocyte apoptosis (RILA) correlates with the severity of radiation toxicity.

Mots clés

Epinal adverse event, individual radiation sensitivity, late radiation-induced toxicity, prostate cancer, radiation-induced lymphocyte apoptosis

Référence

Oncotarget. 2018 Aug 24;9(66):32680-32689