Inhibition of the RhoGTPase Cdc42 by ML141 enhances hepatocyte differentiation from human adipose-derived mesenchymal stem cells via the Wnt5a/PI3K/miR-122 pathway: impact of the age of the donor.

Fiche publication

Date publication

juin 2018

Journal

Stem cell research & therapy

Auteurs

Membres identifiés du Cancéropôle Est :
Pr QUILLIOT Didier

Tous les auteurs :
Chaker D, Mouawad C, Azar A, Quilliot D, Achkar I, Fajloun Z, Makdissy N

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/29921325

Résumé

Human adipose-derived mesenchymal stem cells (hADSCs) are promising cells that may promote hepatocyte differentiation (Hep-Dif) and improve liver function, but the involvement of Cdc42, a key small RhoGTPase which plays a crucial role in aging, is still not well established. We hypothesized that the inhibition of Cdc42 may rescue the hepatogenic potential of hADSCs derived from aged donors.