PET imaging of Ga-NODAGA-RGD, as compared with F-fluorodeoxyglucose, in experimental rodent models of engrafted glioblastoma.

Date publication

juin 2018

Journal

EJNMMI research

Auteurs

Membres identifiés du Cancéropôle Est :
Pr KARCHER Gilles , Pr MARIE Pierre-Yves , Dr PINEL Sophie

Tous les auteurs :
Isal S, Pierson J, Imbert L, Clement A, Collet C, Pinel S, Veran N, Reinhard A, Poussier S, Gauchotte G, Frezier S, Karcher G, Marie PY, Maskali F

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/29904818

Résumé

Tracers triggering αvβ3 integrins, such as certain RGD-containing peptides, were found promising in previous pilot studies characterizing high-grade gliomas. However, only limited comparisons have been performed with current PET tracers. This study aimed at comparing the biodistribution of F-fluorodeoxyglucose (F-FDG) with that of Ga-NODAGA-RGD, an easily synthesized monomeric RGD compound with rapid kinetics, in two different rodent models of engrafted human glioblastoma.

Mots clés

18F-FDG, 68Ga-NODAGA-RGD, Glioblastoma, PET, αvβ3 integrin

Référence

EJNMMI Res. 2018 Jun 15;8(1):51