Portal Inflow Modulation by Somatostatin After Major Liver Resection: A Pilot Study.

Date publication

juin 2018

Journal

Annals of surgery

Auteurs

Membres identifiés du Cancéropôle Est :
Pr PESSAUX Patrick

Tous les auteurs :
Rhaiem R, Piardi T, Chetboun M, Pessaux P, Lestra T, Memeo R, Kianmanesh R, Sommacale D

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/29189385

Résumé

: Major hepatectomy (MH) can lead to an increasing portal vein pressure (PVP) and to lesions of the hepatic parenchyma. Several reports have assessed the deleterious effect of a high posthepatectomy PVP on the postoperative course of MH. Thus, several surgical modalities of portal inflow modulation (PIM) have been described. As for pharmacological modalities, experimental studies showed a potential efficiency of Somatostatin to reduce PVP and flow. To our knowledge, no previous clinical reports of PIM using somatostatin are available. Herein, we report the results of PIM using somatostatin in 10 patients who underwent MH with post-hepatectomy PVP > 20 mmHg. Our results suggest Somatostatin could be considered as an efficient reversible PIM when PVP decrease is above 2.5 mmHg.

Référence

Ann. Surg.. 2018 Jun;267(6):e101-e103