A multi-scale analysis of bull sperm methylome revealed both species peculiarities and conserved tissue-specific features.

Fiche publication

Date publication

mai 2018

Journal

BMC genomics

Auteurs

Membres identifiés du Cancéropôle Est :
Dr WEBER Mickaël

Tous les auteurs :
Perrier JP, Sellem E, Prézelin A, Gasselin M, Jouneau L, Piumi F, Al Adhami H, Weber M, Fritz S, Boichard D, Le Danvic C, Schibler L, Jammes H, Kiefer H

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/29843609

Résumé

Spermatozoa have a remarkable epigenome in line with their degree of specialization, their unique nature and different requirements for successful fertilization. Accordingly, perturbations in the establishment of DNA methylation patterns during male germ cell differentiation have been associated with infertility in several species. While bull semen is widely used in artificial insemination, the literature describing DNA methylation in bull spermatozoa is still scarce. The purpose of this study was therefore to characterize the bull sperm methylome relative to both bovine somatic cells and the sperm of other mammals through a multiscale analysis.