Fiche publication
Date publication
septembre 2013
Journal
Journal of lipid research
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BERNARD Alain
Tous les auteurs :
Chevrot M, Bernard A, Ancel D, Buttet M, Martin C, Abdoul-Azize S, Merlin JF, Poirier H, Niot I, Khan NA, Passilly-Degrace P, Besnard P
Lien Pubmed
Résumé
A relationship between orosensory detection of dietary lipids, regulation of fat intake, and body mass index was recently suggested. However, involved mechanisms are poorly understood. Moreover, whether obesity can directly modulate preference for fatty foods remains unknown. To address this question, exploration of the oral lipid sensing system was undertaken in diet-induced obese (DIO) mice. By using a combination of biochemical, physiological, and behavioral approaches, we found that i) the attraction for lipids is decreased in obese mice, ii) this behavioral change has an orosensory origin, iii) it is reversed in calorie-restricted DIO mice, revealing an inverse correlation between fat preference and adipose tissue size, iv) obesity suppresses the lipid-mediated downregulation of the lipid-sensor CD36 in circumvallate papillae, usually found during the refeeding of lean mice, and v) the CD36-dependent signaling cascade controlling the intracellular calcium levels ([Ca(2+)]i) in taste bud cells is decreased in obese mice. Therefore, obesity alters the lipid-sensing system responsible for the oral perception of dietary lipids. This phenomenon seems to take place through a CD36-mediated mechanism, leading to changes in eating behavior.
Mots clés
Adipose Tissue, drug effects, Animals, Antigens, CD36, metabolism, Behavior, Animal, Calcium Signaling, drug effects, Diet, High-Fat, adverse effects, Dietary Fats, pharmacology, Food Preferences, drug effects, Mice, Mice, Inbred C57BL, Obesity, etiology, Taste Perception, drug effects, Tongue, cytology
Référence
J. Lipid Res.. 2013 Sep;54(9):2485-94
