Fiche publication
Date publication
avril 2017
Journal
Developmental dynamics : an official publication of the American Association of Anatomists
Auteurs
Membres identifiés du Cancéropôle Est :
Pr POLETTE Myriam
Tous les auteurs :
Francart ME, Lambert J, Vanwynsberghe AM, Thompson EW, Bourcy M, Polette M, Gilles C
Lien Pubmed
Résumé
Epithelial-Mesenchymal Transitions (EMT) associated with metastatic progression may contribute to the generation of hybrid phenotypes capable of plasticity. This cellular plasticity would provide tumor cells with an increased potential to adapt to the different microenvironments encountered during metastatic spread. Understanding how EMT may functionally equip Circulating Tumor Cells (CTCs) with an enhanced competence to survive in the blood stream and niche in the colonized organs has thus become a major cancer research axis. We summarize here clinical data with CTC endpoints involving EMT. We then review the work functionally linking EMT programs to CTC biology and deciphering molecular EMT-driven mechanisms supporting their metastatic competence. This article is protected by copyright. All rights reserved.
Mots clés
CTC, EMP, EMT, coagulation, early metastasis
Référence
Dev. Dyn.. 2017 Apr;:
