Fiche publication
Date publication
janvier 2005
Journal
Vitamins and hormones
Auteurs
Membres identifiés du Cancéropôle Est :
Pr DEDIEU Stéphane
Tous les auteurs :
Lefebvre P, Martin PJ, Flajollet S, Dedieu S, Billaut X, Lefebvre B
Lien Pubmed
Résumé
Vitamin A derivatives plays a crucial role in embryonic development, as demonstrated by the teratogenic effect of either an excess or a deficiency in vitamin A. Retinoid effects extend however beyond embryonic development, and tissue homeostasis, lipid metabolism, cellular differentiation and proliferation are in part controlled through the retinoid signaling pathway. Retinoids are also therapeutically effective in the treatment of skin diseases (acne, psoriasis and photoaging) and of some cancers. Most of these effects are the consequences of retinoic acid receptors activation, which triggers transcriptional events leading either to transcriptional activation or repression of retinoid-controlled genes. Synthetic molecules are able to mimic part of the biological effects of the natural retinoic acid receptors, all-trans retinoic acid. Therefore, retinoic acid receptors are considered as highly valuable therapeutic targets and limiting unwanted secondary effects due to retinoid treatment requires a molecular knowledge of retinoic acid receptors biology. In this review, we will examine experimental evidence which provide a molecular basis for the pleiotropic effects of retinoids, and emphasize the crucial roles of coregulators of retinoic acid receptors, providing a conceptual framework to identify novel therapeutic targets.
Mots clés
Animals, Congenital Abnormalities, Gene Expression Regulation, Humans, Receptors, Retinoic Acid, chemistry, Retinoids, pharmacology, Retinol-Binding Proteins, physiology, Transcription Factor AP-1, Transcription, Genetic, Transcriptional Activation, Vitamin A Deficiency
Référence
Vitam. Horm.. 2005 ;70:199-264
