Dental pulp stem cell-derived conditioned medium: an attractive alternative for regenerative therapy.

Fiche publication

Date publication

août 2018

Journal

Tissue engineering. Part B, Reviews

Auteurs

Membres identifiés du Cancéropôle Est :
Pr MENU Patrick

Tous les auteurs :
Kichenbrand C, Velot É, Menu P, Moby V

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/30156475

Résumé

Mesenchymal stem cells have a lot of potential in regenerative medicine and mesenchymal stem cell-based therapies are currently explored in numerous research fields. Among these cells, deciduous or permanent dental pulp-mesenchymal stem cells represent a promising option in tissue engineering. This expectation is based on their capacity to self-renew, to repair various damaged tissues and organs due to their multipotency, as well as their ability to modulate immune system. They present other advantages such as the harvesting by a simple, painless and non-invasive procedure and the absence of ethical considerations. The role played by these cells in the reparative process is mainly attributed to paracrine mechanisms mediated by their secreted factors, namely the secretome. The secreted factors can be found in the cell culture medium, called conditioned medium. Moreover, conditioned medium presents many advantages compared to cells such as possible use in allogeneic therapies. This mini review aims at investigating the therapeutic use of dental pulp mesenchymal stem cell-derived conditioned medium, in order to develop cell-free therapies. The analysis of the available literature illustrates its massive panel of potential applications: mainly reduction of inflammation, promotion of angiogenesis and neurogenesis, reduction of stroke or ischemia, and organ regeneration. Furthermore, studies often highlight its superiority over the other sources of conditioned medium derived from other stem cells for the same applications. Dental pulp mesenchymal stem cell-derived conditioned medium is an attractive non-invasive and acellular tool for therapeutic approaches in regenerative medicine. This promising novel approach should be further explored for clinical applications.