Differentiating Merkel cell carcinoma of lymph nodes without a detectable primary skin tumor from other metastatic neuroendocrine carcinomas: The ELECTHIP criteria.

Date publication

mai 2018

Journal

Journal of the American Academy of Dermatology

Auteurs

Membres identifiés du Cancéropôle Est :
Pr AUBIN François

Tous les auteurs :
Kervarrec T, Zaragoza J, Gaboriaud P, Le Gouge A, Beby-Defaux A, Le Corre Y, Hainaut-Wierzbicka E, Aubin F, Bens G, Michenet P, Maillard H, Touzé A, Samimi M, Guyétant S

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/29180096

Résumé

Merkel cell carcinoma (MCC) can present as a cutaneous tumor or a lymph node metastasis without a primary tumor. MCC presenting without a primary tumor (MCCWOPT) can be misinterpreted on histologic examination as lymph node metastasis (LNM) from another neuroendocrine carcinoma (LNMNEC). However, this distinction is crucial for therapeutic management.

Mots clés

CK20, MCPyV, Merkel cell carcinoma, TTF-1, differential diagnosis, lymph nodes, metastasis, neuroendocrine carcinoma

Référence

J. Am. Acad. Dermatol.. 2018 May;78(5):964-972.e3