Reduction-rebridging strategy for the preparation of ADPN-based antibody-drug conjugates.

Date publication

mai 2018

Journal

MedChemComm

Auteurs

Membres identifiés du Cancéropôle Est :
Dr CIANFERANI Sarah , Dr WAGNER Alain , Dr KOLODYCH Sergii , Dr KONIEV Sasha

Tous les auteurs :
Koniev O, Dovgan I, Renoux B, Ehkirch A, Eberova J, Cianférani S, Kolodych S, Papot S, Wagner A

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/30108971

Résumé

The reduction-rebridging strategy is a powerful method for the preparation of stable and homogeneous antibody-drug conjugates (ADCs). In this communication, we describe the development of the arylene-dipropiolonitrile (ADPN) functional group for the rebridging of reduced disulphide bonds and its application in the preparation of potent and selective ADCs.

Référence

Medchemcomm. 2018 May 1;9(5):827-830