Fiche publication


Date publication

avril 2018

Journal

Bone marrow transplantation

Auteurs

Membres identifiés du Cancéropôle Est :
Dr BERCEANU Ana , Pr DECONINCK Eric


Tous les auteurs :
Bellanger AP, Berceanu A, Rocchi S, Valot B, Fontan J, Chauchet A, Belin N, Scherer E, Deconinck E, Navellou JC, Millon L

Résumé

Mucormycosis is an invasive mold infection, frequently fatal in immunocompromised patients. We report the case of a patient with chronic lymphocytic leukemia admitted to the hematology unit for febrile aplasia. Pulmonary lesions suggesting a fungal infection expanded/increased despite a combination of posaconazole and liposomal amphotericin B. The fungal biomarkers performed repeatedly were negative. At D65 after chemotherapy a bronchial biopsy was positive for Cunninghamella bertholletiae. The patient died despite appropriate antifungal management. A qPCR targeting Cunninghamella was developed a posteriori, and a retrospective analysis showed that a sample was positive more than 30 days before culture-based identification could be made.

Référence

Bone Marrow Transplant.. 2018 Apr 30;: