Molecular analysis of differential antiproliferative activity of resveratrol, epsilon viniferin and labruscol on melanoma cells and normal dermal cells.

Fiche publication

Date publication

avril 2018

Journal

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Auteurs

Membres identifiés du Cancéropôle Est :
Pr DELMAS Dominique , Pr MARTINY Laurent , Pr TARPIN Michel , Dr AIRES Virginie

Tous les auteurs :
Nivelle L, Aires V, Rioult D, Martiny L, Tarpin M, Delmas D

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/29684496

Résumé

Very recently, we have produced new resveratrol derived compounds, especially labruscol by culture of elicited grapevine cell suspensions (Vitis labrusca L.). This new polyphenolic oligomer could function as cancer chemopreventive agent in similar manner of resveratrol. In this study, we have determined the efficiency of resveratrol, ε-viniferin and the labruscol on human melanoma cell with or without metastatic phenotype. Our results show a differential activity of the three compounds where the resveratrol remains the polyphenolic compound with the most effective action compared to other oligomers. These three compounds block cell cycle of melanoma cells in S phase by modulating key regulators of cell cycle i.e. cyclins A, E, D1 and their cyclin-dependent kinases 1 and 2. These effects are associated with an increase of cell death while these compounds have no cytotoxic action on normal human dermal fibroblasts.