Development of a porcine beating-heart model of self-myocardial retroperfusion: evaluation of hemodynamic and cardiac responses to ischemia and clinical applications.

Date publication

juin 2018

Journal

The Journal of cardiovascular surgery

Auteurs

Membres identifiés du Cancéropôle Est :
Pr GAUCHOTTE Guillaume

Tous les auteurs :
Grandmougin D, Casse JM, Chalon A, Luo Y, Falanga A, Marie V, Groubatch-Joineau F, Mourer B, Grandmougin M, Grandmougin D, Gauchotte G, Maureira JP, Tran N

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/29327562

Résumé

Retrograde perfusion into the coronary sinus is used to deliver cardioplegia. We developed an in-vivo porcine beating-heart model of self-myocardial retroperfusion (SMR) using the venous route to supply myocardial oxygenation and sought to assess hemodynamic and cardiac responses triggered by SMR before and after a prolonged occlusion of the LAD.

Mots clés

Animals, Aorta, physiopathology, Coronary Circulation, Coronary Sinus, physiopathology, Disease Models, Animal, Echocardiography, Doppler, Hemodynamics, Male, Myocardial Contraction, Myocardial Ischemia, blood, Oxygen, blood, Perfusion, adverse effects, Stroke Volume, Sus scrofa, Time Factors, Ventricular Function, Left

Référence

J Cardiovasc Surg (Torino). 2018 Jun;59(3):438-452