Fiche publication
Date publication
avril 2018
Journal
Breast cancer research : BCR
Auteurs
Membres identifiés du Cancéropôle Est :
Dr MAUGARD Christine
,
Pr FAIVRE Laurence
Tous les auteurs :
Renault AL, Mebirouk N, Fuhrmann L, Bataillon G, Cavaciuti E, Le Gal D, Girard E, Popova T, La Rosa P, Beauvallet J, Eon-Marchais S, Dondon MG, d'Enghien CD, Laugé A, Chemlali W, Raynal V, Labbé M, Bièche I, Baulande S, Bay JO, Berthet P, Caron O, Buecher B, Faivre L, Fresnay M, Gauthier-Villars M, Gesta P, Janin N, Lejeune S, Maugard C, Moutton S, Venat-Bouvet L, Zattara H, Fricker JP, Gladieff L, Coupier I, ,,,Chenevix-Trench G, Hall J, Vincent-Salomon A, Stoppa-Lyonnet D, Andrieu N, Lesueur F
Lien Pubmed
Résumé
The ataxia telangiectasia mutated (ATM) gene is a moderate-risk breast cancer susceptibility gene; germline loss-of-function variants are found in up to 3% of hereditary breast and ovarian cancer (HBOC) families who undergo genetic testing. So far, no clear histopathological and molecular features of breast tumours occurring in ATM deleterious variant carriers have been described, but identification of an ATM-associated tumour signature may help in patient management.
Mots clés
ATM, Breast tumour, Copy number, Genetic instability, Genomic signature, Loss of heterozygosity, OncoScan array, Pathology
Référence
Breast Cancer Res.. 2018 Apr 17;20(1):28
