In situ chemical behaviour of methylisothiazolinone (MI) and methylchloroisothiazolinone (MCI) in reconstructed human epidermis: a new approach to the cross-reactivity issue.

Date publication

mars 2016

Journal

Contact dermatitis

Auteurs

Membres identifiés du Cancéropôle Est :
Pr NAMER Izzie-Jacques

Tous les auteurs :
Debeuckelaere C, Moussallieh FM, Elbayed K, Namer IJ, Berl V, Giménez-Arnau E, Lepoittevin JP

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/26899805

Résumé

Methylisothiazolinone (MI) [with methylchloroisothiazolinone (MCI) in a ratio of 1:3, a well-recognized allergenic preservative] was released as an individual preservative in the 2000s for industrial products and in 2005 for cosmetics. The high level of exposure to MI since then has provoked an epidemic of contact allergy to MI, and an increase in MI/MCI allergy. There are questions concerning the MI/MCI cross-reaction pattern.

Mots clés

Cross Reactions, Cysteine, chemistry, Epidermis, chemistry, Histidine, analogs & derivatives, Humans, Lysine, analogs & derivatives, Magnetic Resonance Spectroscopy, Sulfhydryl Compounds, chemistry, Thiazoles, chemistry

Référence

Contact Derm.. 2016 Mar;74(3):159-67