Ictal and interictal perfusion variations measured by SISCOM analysis in typical childhood absence seizures.

Date publication

décembre 2004

Journal

Epileptic disorders : international epilepsy journal with videotape

Auteurs

Membres identifiés du Cancéropôle Est :
Pr NAMER Izzie-Jacques

Tous les auteurs :
Nehlig A, Valenti MP, Thiriaux A, Hirsch E, Marescaux C, Namer IJ

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/15634621

Résumé

Single photon emission computed tomography (SPECT) is currently used in the presurgical evaluation of medically intractable partial epilepsies, but not very often, in generalized epilepsy. In the present study, we used the SISCOM procedure, which represents the fusion of MRI and ictal-interictal difference SPECT images using (99m)Tc-ECD, to study cerebral blood flow changes during the ictal and postictal phases of typical childhood absence seizures. The study was performed on four children with typical, difficult to treat absence seizures, aged 10-13 years at the time of scan. The delay between the onset of absence seizures and the injection of (99m)Tc-ECD was carefully noted. One scan was performed during the ictal phase and showed diffuse blood flow decreases, while the three other scans performed during the postictal phase, showed generalized blood flow increase. These data are consistent with most previous data reporting generalized changes in functional activity, not limited to the thalamo-cortical circuit in which absence seizures originate, and a decrease in cerebral blood flow during the ictal phase. Our data are concordant with the hypothesis that neuronal activity underlying the occurrence of spike-and-wave discharges does not seem to require an increase in metabolic demand and blood flow rates. [Published with videosequences].

Mots clés

Adolescent, Anticonvulsants, therapeutic use, Blood Flow Velocity, drug effects, Brain, blood supply, Cerebral Cortex, blood supply, Child, Cysteine, analogs & derivatives, Dominance, Cerebral, drug effects, Drug Therapy, Combination, Electroencephalography, drug effects, Energy Metabolism, drug effects, Epilepsy, Absence, diagnosis, Evoked Potentials, drug effects, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Angiography, Male, Neural Pathways, blood supply, Organotechnetium Compounds, Radiopharmaceuticals, Regional Blood Flow, physiology, Sensitivity and Specificity, Thalamus, blood supply, Tomography, Emission-Computed, Single-Photon

Référence

Epileptic Disord. 2004 Dec;6(4):247-53