Predictive value of cortical injury for the development of temporal lobe epilepsy in 21-day-old rats: an MRI approach using the lithium-pilocarpine model.

Date publication

octobre 2002

Journal

Epilepsia

Auteurs

Membres identifiés du Cancéropôle Est :
Pr NAMER Izzie-Jacques

Tous les auteurs :
Roch C, Leroy C, Nehlig A, Namer IJ

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/12366725

Résumé

Patients with temporal lobe epilepsy (TLE) usually had an initial precipitating injury in early childhood. However, epilepsy does not develop in all children who have undergone an early insult. As in patients, the consequences of the lithium-pilocarpine-induced status epilepticus (SE) are age dependent, and only a subset of 21-day-old rats will develop epilepsy. Thus with magnetic resonance imaging (MRI), we explored the differences in the evolution of lesions in these two populations of rats.

Mots clés

Age Factors, Animals, Brain Diseases, chemically induced, Cerebral Cortex, drug effects, Disease Models, Animal, Entorhinal Cortex, drug effects, Epilepsy, Temporal Lobe, chemically induced, Female, Lithium Chloride, pharmacology, Magnetic Resonance Imaging, statistics & numerical data, Male, Pilocarpine, pharmacology, Probability, Rats, Rats, Sprague-Dawley, Status Epilepticus, chemically induced

Référence

Epilepsia. 2002 Oct;43(10):1129-36