Fiche publication
Date publication
avril 2018
Journal
FEBS letters
Auteurs
Membres identifiés du Cancéropôle Est :
Dr ROCHETTE-EGLY Cécile
Tous les auteurs :
Carrier M, Lutzing R, Gaouar S, Rochette-Egly C
Lien Pubmed
Résumé
The nuclear retinoic acid (RA) receptors (RARα, β and γ) are ligand-dependent regulators of transcription. Upon activation by RA, they are recruited at the promoters of target genes together with several coregulators. Then, they are degraded by the ubiquitin proteasome system. Here, we report that the degradation of the RARα subtype involves ubiquitination and the tripartite motif protein TRIM24, which was originally identified as a ligand-dependent corepressor of RARα. We show that in response to RA, TRIM24 serves as an adapter linking RARα to the proteasome for its degradation. In addition, TRIM24 and the proteasome are recruited with RARα to the promoters of target genes and thus are inherently linked to RARα transcriptional activity.
Mots clés
TRIM24, degradation, proteasome, retinoic acid receptor, transcription, ubiquitin
Référence
FEBS Lett.. 2018 Apr;592(8):1426-1433
