Primary cutaneous ganglioneuroma: anatomoclinical study of 4 cases with focus on Merkel cells.

Fiche publication

Date publication

mars 2018

Journal

Journal of cutaneous pathology

Auteurs

Membres identifiés du Cancéropôle Est :
Pr CRIBIER Bernard

Tous les auteurs :
Romero-Pérez D, Jegou MH, Lecointre C, Penchet I, Cribier B

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/29569258

Résumé

Cutaneous ganglioneuromas (CGNs) are exceptional. We aim to describe the anatomoclinical profile of primary CGN and report 4 cases. Patients were 2 men and 2 women aged 53 to 76 years, who had flesh-colored nodules on the back, associated with adjacent keratotic changes, that is, epidermal nevus (1 case) or seborrheic keratosis (3 cases). Histopathology showed ganglion cells within a proliferation of Schwann cells. The epidermis was acanthotic, associated with sebaceous induction in 2 cases, with follicular hyperplasia as in fibroepithelial tumors (1 case) or with tricholemmoma (2 cases). Cytokeratin-20 immunostaining showed Merkel cells in the epidermis. A higher density of Merkel cells was observed in BerEP4+ follicular structures. Along with 16 published cases, our study indicates that a nodule associated with seborrheic keratosis on the back may represent a CGN, a complex mesenchymal and epidermal/follicular lesion of neuroectodermal lineage, associating neuronal proliferation and Merkel cell hyperplasia with follicular induction.