Fiche publication
Date publication
mars 2018
Journal
Chronobiology international
Auteurs
Membres identifiés du Cancéropôle Est :
Dr GARRIDO Carmen
,
Pr CHLUBA Johanna
Tous les auteurs :
Mennetrier L, Lopez T, Pruvot B, Yousfi N, Armant O, Hazhaz H, Lhuissiez V, Garrido C, Chluba J
Lien Pubmed
Résumé
HSF1 is a transcription factor that plays a key role in circadian resetting by temperature. We have used zebrafish embryos to decipher the roles of zHsf1, heat and light on zper2 transcription in vivo. Our results show that heat shock (HS) stimulated zper2 expression in the dark but has no cumulative effect combined with light. After light exposition, zper2 expression was 2.7 fold increased threefold in the hsf1-morphants in comparison to control embryos. Our results show that zHsf1 plays a positive role in HS-driven expression of zper2 in the dark but seems to act as an attenuator in the presence light.
Mots clés
crispants, morpholino knockdown, zHSF1, zebrafish, zper2
Référence
Chronobiol. Int.. 2018 Mar 6;:1-8
