Fiche publication
Date publication
mars 2018
Journal
Critical reviews in oncology/hematology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr ANTONI Delphine
,
Pr NOEL Georges
,
Dr LE FEVRE Clara
Tous les auteurs :
Pin Y, Paix A, Le Fèvre C, Antoni D, Blondet C, Noël G
Lien Pubmed
Résumé
Palliative radiotherapy has been shown to have effects on Quality of Life during painful bone metastasis. This review aimed to determine equivalence in pain relief (PR) and retreatment rate (RR) using both single and multi-fraction irradiations, based on evaluation of the trial's quality. We performed a systematic review since ICRU 50 Report (1993) to June 2017, then evaluated trials for reproducibility and good methodology criteria. We found five studies that were reproducible in both dose and volume prescription. One study used three-dimensional (3D) treatment planning. Equivalence between single and multi-fraction schedules was demonstrated for PR after 3 months, but a 2-3 time RR appeared after single-fraction schedules, notably in the first year after treatment (primarily during the first four months). Reserving long course therapy for well-preserved patients would allow for better long-term efficacy with lower RR, while altered patients would suffer less from single-fraction treatments. It appears that life expectancy might not be used as a criterion for this choice.
Mots clés
Bone metastasis, Bone neoplasms, Bone secondary, Dose prescription, Fractionation, Good methodology, Pain management, Pain relief, Palliative care, Radiation oncology, Reirradiation, Retreatment rate, Volume definition
Référence
Crit. Rev. Oncol. Hematol.. 2018 Mar;123:132-137
