Brain metabolism and related connectivity in patients with acrophobia treated by virtual reality therapy: an F-FDG PET pilot study sensitized by virtual exposure.

Date publication

octobre 2018

Journal

EJNMMI research

Auteurs

Membres identifiés du Cancéropôle Est :
Pr VERGER Antoine

Tous les auteurs :
Verger A, Malbos E, Reynaud E, Mallet P, Mestre D, Pergandi JM, Khalfa S, Guedj E

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/30276498

Résumé

The aim of this pilot study is to investigate the impact of virtual reality exposure therapy (VRET) on brain metabolism and connectivity. Eighteen patients with acrophobia were assessed by an F-FDG PET scan sensitized by virtual exposure before treatment, and nine of them were assessed again after eight sessions of VRET. Statistical Parametric Mapping was used to study the correlations between metabolism and pretherapeutic clinical scores and to compare metabolism before and after VRET (p voxel < 0.005, corrected for cluster volume). Metabolic connectivity was evaluated through interregional correlation analysis.

Mots clés

Acrophobia, Metabolic connectivity, PET, Virtual reality exposure therapy

Référence

EJNMMI Res. 2018 Oct 1;8(1):93