Fiche publication
Date publication
février 2018
Journal
Circulation research
Auteurs
Membres identifiés du Cancéropôle Est :
Dr ESCHWEGE Pascal
,
Pr HUBERT Jacques
Tous les auteurs :
Benetos A, Toupance S, Gautier S, Labat C, Kimura M, Rossi PM, Settembre N, Hubert J, Frimat L, Bertrand B, Boufi M, Flecher X, Sadoul N, Eschwege P, Kessler M, Tzanetakou IP, Doulamis IP, Konstantopoulos P, Tzani A, Korou M, Gkogkos A, Perreas K, Menenakos E, Samanidis G, Vasiloglou-Gkanis M, Kark JD, Malikov S, Verhulst S, Aviv A
Lien Pubmed
Résumé
Short telomere length (TL) in leukocytes is associated with atherosclerotic cardiovascular disease (ASCVD). It is unknown whether this relationship stems from having inherently short leukocyte TL (LTL) at birth or a faster LTL attrition thereafter. LTL represents TL in the highly proliferative hematopoietic system, whereas TL in skeletal muscle represents a minimally replicative tissue.
Mots clés
aging, atherosclerosis, biopsy, leukocytes, muscle, telomere
Référence
Circ. Res.. 2018 Feb 16;122(4):616-623
