Fiche publication
Date publication
octobre 2018
Journal
Molecular cell
Auteurs
Membres identifiés du Cancéropôle Est :
Dr TORA Laszlo
Tous les auteurs :
Timmers HTM, Tora L
Lien Pubmed
Résumé
Transcript buffering involves reciprocal adjustments between overall rates in mRNA synthesis and degradation to maintain similar cellular concentrations of mRNAs. This phenomenon was first discovered in yeast and encompasses coordination between the nuclear and cytoplasmic compartments. Transcript buffering was revealed by novel methods for pulse labeling of RNA to determine in vivo synthesis and degradation rates. In this Perspective, we discuss the current knowledge of transcript buffering. Emphasis is placed on the future challenges to determine the nature and directionality of the buffering signals, the generality of transcript buffering beyond yeast, and the molecular mechanisms responsible for this balancing.
Mots clés
CCR4-NOT, SAGA, TFIID, XRN1, deadenylation, decapping, mRNA degradation, mRNA synthesis, pol II transcription, transcript buffering
Référence
Mol. Cell. 2018 Oct 4;72(1):10-17
