Fiche publication
Date publication
octobre 2018
Journal
Medicine
Auteurs
Membres identifiés du Cancéropôle Est :
Dr EYMARD Jean-Christophe
,
Pr PAPATHANASSIOU Dimitri
Tous les auteurs :
Dejust S, Morland D, Bruna-Muraille C, Eymard JC, Yazbek G, Savoye AM, Papathanassiou D
Lien Pubmed
Résumé
The everolimus-exemestane combination is indicated in advanced breast cancer treatment and usually well tolerated. The objective of the study was to determine the frequency of everolimus lung side effects and investigate their imaging characteristics on positron emission tomography with 18F-fluoro-deoxy-glucose combined with computerized tomography (F-FDG PET/CT).Our single-center retrospective descriptive study systematically included all patients with metastatic breast cancer treated by this combination (n = 29 representing 57 F-FDG PET/CT). Number of segments involved was quantified. Maximum standardized uptake value (SUVmax), average standardized uptake value (SUVmean), metabolic target volume (MTV), and total lesion glycolysis (TLG) were measured. Severe pneumopathy was studied by subgroup analysis.Pleuroparenchymal anomalies rate detected on F-FDG PET/CT was 62%. Alveolar-interstitial lesions were mainly observed (89%) and affected 2.8 segments (0.5-11.5) with a median of 2 segments. S7 and S10 were the most involved segments with SUVmax 3.9 (1.3-8.8) and SUVmean 2.2 (0.7-4.9). Statistically significant difference (P = .02) was found with number of segment involved to characterize severe pneumopathy (average of 6.3 segments [2.5-11.5] vs 1.9 segments [0.5-8] for interstitial lung disease) but not with SUVmax, SUVmean, MTV, TLG (P = .14, 0.22, 0.22, and 0.17, respectively).The F-FDG PET/CT could highlight pulmonary everolimus side effects, with a typical imaging pattern: alveolar-interstitial opacities associated with moderate uptake, more or less extensive, mainly affecting the lower lobes. Rarely, a pseudotumoral aspect may be detected, corresponding to a pitfall. MTV or TLG showed a tendency to differentiate severe pneumopathy vs interstitial lung disease but no statistically significant differences was observed contrarily to the number of segments involved. Further studies are necessary to determine if the F-FDG PET/CT could early predict adverse effects of mTOR inhibitors.
Mots clés
Adult, Aged, Aged, 80 and over, Androstadienes, administration & dosage, Breast Neoplasms, drug therapy, Everolimus, adverse effects, Female, Fluorodeoxyglucose F18, Glycolysis, drug effects, Humans, Lung Diseases, Interstitial, chemically induced, Middle Aged, Positron Emission Tomography Computed Tomography, TOR Serine-Threonine Kinases, antagonists & inhibitors, Tumor Burden
Référence
Medicine (Baltimore). 2018 Oct;97(40):e12518
