Fiche publication
Date publication
février 2018
Journal
The journals of gerontology. Series A, Biological sciences and medical sciences
Auteurs
Membres identifiés du Cancéropôle Est :
Pr FAIVRE Béatrice
,
Dr RIALLAND Mickaël
Tous les auteurs :
Connat JL, Dumont A, Rialland M, Faivre B, Sorci G
Lien Pubmed
Résumé
Aging is often associated with elevated levels of low grade inflammation supposed to drive age-associated diseases. Here, we conducted a cross-sectional study on 58 healthy volunteers, aged from 19 to 81, to investigate the relationship between age and the expression of three inflammasome component genes (Nlrp3, Asc, Casp1), the up-stream transcription factor NFkB, and the pro-inflammatory cytokine Il-1 in leukocytes. We also assessed C-reactive protein (CRP) and IL-1 in plasma, as additional inflammatory markers. We did not find any support to the hypothesis that inflammasone activation increases with age. Expression of Asc, Casp1, NFkB and Il-1 did not vary with age, body mass index, and CRP levels. In addition, expression did not differ between males and females or between smokers and non-smokers. A notable exception was the expression of Nlrp3 which varied non-linearly with age. Specifically, Nlrp3 expression strongly declined during aging, in subjects who were between 50 and 81 years old. CRP was higher in women and increased as a function of age-corrected body mass index, while only four subjects showed detectable amount of IL-1 in plasma. Further work on larger cohorts with a longitudinal monitoring should be conducted to corroborate the finding that healthy aging is associated with a decrease in inflammasome activation.
Référence
J. Gerontol. A Biol. Sci. Med. Sci.. 2018 Feb 3;:
