Fiche publication
Date publication
janvier 2018
Journal
Viruses
Auteurs
Membres identifiés du Cancéropôle Est :
Dr TRAVE Gilles
Tous les auteurs :
Suarez I, Trave G
Lien Pubmed
Résumé
Since their discovery in the mid-eighties, the main papillomavirus oncoproteins E6 and E7 have been recalcitrant to high-resolution structure analysis. However, in the last decade a wealth of three-dimensional information has been gained on both proteins whether free or complexed to host target proteins. Here, we first summarize the diverse activities of these small multifunctional oncoproteins. Next, we review the available structural data and the new insights they provide about the evolution of E6 and E7, their multiple interactions and their functional variability across human papillomavirus (HPV) species.
Mots clés
NMR, X-ray, oncoproteins, papillomaviruses, structure, virus-host interactomics
Référence
Viruses. 2018 01 15;10(1):
