Antitumor Effects of Lidocaine on Human Breast Cancer Cells: An and Experimental Trial.

Date publication

janvier 2018

Journal

Anticancer research

Auteurs

Membres identifiés du Cancéropôle Est :
Pr MATHELIN Carole , Dr TOMASETTO Catherine , Pr AKLADIOS Chérif

Tous les auteurs :
Chamaraux-Tran TN, Mathelin C, Aprahamian M, Joshi GP, Tomasetto C, Diemunsch P, Akladios C

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/29277761

Résumé

Retrospective studies have suggested a protective effect of regional anesthesia against recurrence after cancer surgery. But confirmation of the in vivo antitumor effects is lacking. We examined the in vitro antitumor effects of lidocaine on various breast cancer cell lines and then assessed these properties in vivo at clinically relevant concentrations.

Mots clés

Anesthetics, Local, pharmacology, Animals, Antineoplastic Agents, pharmacology, Breast Neoplasms, drug therapy, Cell Line, Tumor, Cell Movement, drug effects, Cell Survival, drug effects, Female, Humans, Lidocaine, pharmacology, Mice, SCID, Peritoneal Neoplasms, drug therapy

Référence

Anticancer Res.. 2018 01;38(1):95-105