Polymorphisms in EGFR and IL28B are associated with spontaneous clearance in an HCV-infected iranian population.

Date publication

septembre 2015

Auteurs

Membres identifiés du Cancéropôle Est :
Pr BAHRAM Siamak

Tous les auteurs :
Carapito R, Poustchi H, Kwemou M, Untrau M, Sharifi AH, Merat S, Haj-Sheykholeslami A, Jabbari H, Esmaili S, Michel S, Toussaint J, Le Gentil M, Ansari-Moghaddam A, Radosavljevic M, Etemadi A, Georgel P, Malekzadeh R, Bahram S

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/26378651

Résumé

Although most hepatitis C virus (HCV)-infected individuals develop chronic infection, about 25% of them are able to clear the virus spontaneously without any therapeutic intervention. The aim of the present study was to identify genes associated with spontaneous HCV clearance in a population of Iranian patients. We genotyped 110 single-nucleotide polymorphisms (SNPs) in 59 selected-candidate-genes in a cohort of 107 HCV-infected participants who spontaneously cleared the infection and 176 participants whose infection persisted. Three out of the 110 SNPs were found to be associated with HCV outcome (P-values

Référence

Genes Immun. 2015 Sep 17