Fiche publication
Date publication
janvier 2018
Journal
Archives of cardiovascular diseases
Auteurs
Membres identifiés du Cancéropôle Est :
Dr HERAULT Yann
,
Dr SORG Tania
Tous les auteurs :
Bouabout G, Ayme-Dietrich E, Jacob H, Champy MF, Birling MC, Pavlovic G, Madeira L, Fertak LE, Petit-Demoulière B, Sorg T, Herault Y, Mudgett J, Monassier L
Lien Pubmed
Résumé
Metabolic syndrome is a combination of symptoms including obesity, dyslipidaemia, glucose intolerance and hypertension. Oxidative stress appears to be a pathophysiological factor that links these signs and encourages progression towards heart failure and diabetes. Nox4 is a hydrogen peroxide nicotinamide adenine dinucleotide phosphate (NADPH) oxidase isoform - found in various cardiovascular cells and tissues, but also in tissues such as the liver - which is involved in glucose and lipid homeostasis.
Mots clés
Angiotensin, Angiotensine, Hypertension, Metabolism, Métabolisme, NADPH oxidase, NADPH oxydase, Nox4
Référence
Arch Cardiovasc Dis. 2018 Jan;111(1):41-52
