Fiche publication
Date publication
septembre 2018
Journal
Marine drugs
Auteurs
Membres identifiés du Cancéropôle Est :
Dr MULLER Christian
Tous les auteurs :
de Vera CR, Díaz Crespín G, Hernández Daranas A, Montalvão Looga S, Lillsunde KE, Tammela P, Perälä M, Hongisto V, Virtanen J, Rischer H, Muller CD, Norte M, Fernández JJ, Souto ML
Lien Pubmed
Résumé
The study of marine natural products for their bioactive potential has gained strength in recent years. Oceans harbor a vast variety of organisms that offer a biological and chemical diversity with metabolic abilities unrivalled in terrestrial systems, which makes them an attractive target for bioprospecting as an almost untapped resource of biotechnological applications. Among them, there is no doubt that microalgae could become genuine "cell factories" for the biological synthesis of bioactive substances. Thus, in the course of inter-laboratory collaboration sponsored by the European Union (7th FP) into the MAREX Project focused on the discovery of novel bioactive compounds of marine origin for the European industry, a bioprospecting study on 33 microalgae strains was carried out. The strains were cultured at laboratory scale. Two extracts were prepared for each one (biomass and cell free culture medium) and, thus, screened to provide information on the antimicrobial, the anti-proliferative, and the apoptotic potential of the studied extracts. The outcome of this study provides additional scientific data for the selection of , , , , and (Pr-3) for further investigation and offers support for the continued research of new potential drugs for human therapeutics from cultured microalgae.
Mots clés
bioactive compound, bioprospecting, blue biotechnology, drug discovery, marine microalgae, marine natural products
Référence
Mar Drugs. 2018 Sep 6;16(9):
