Potential added value of a RT-qPCR method of SOX 11 expression, in the context of a multidisciplinary diagnostic assessment of B cell malignancies.

Date publication

janvier 2018

Journal

Experimental hematology & oncology

Auteurs

Membres identifiés du Cancéropôle Est :
Pr CALLIER Patrick , Dr CASASNOVAS Olivier , Dr FERRAND Christophe , Pr GARNACHE-OTTOU Francine , Dr VERNEREY Dewi

Tous les auteurs :
Magne J, Jenvrin A, Chauchet A, Casasnovas O, Donzel A, Jego L, Aral B, Guy J, Nadal N, Vernerey D, Callier P, Garnache-Ottou F, Ferrand C

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/29484276

Résumé

Expression of SRY [sex-determining region Y]-box11 (SOX11) is specific to mantle cell lymphoma (MCL) and contributes, in conjunction with immunoglobulin variable heavy chain gene mutation status, to the identification of two forms of this disease.

Mots clés

Mantle cell lymphoma, ROC curve analysis-threshold, RT-qPCR-reference genes, SOX11

Référence

Exp Hematol Oncol. 2018 ;7:5