The Ikaros family in lymphocyte development.

Date publication

décembre 2017

Journal

Current opinion in immunology

Auteurs

Membres identifiés du Cancéropôle Est :
Dr CHAN Susan , Dr KASTNER Philippe

Tous les auteurs :
Heizmann B, Kastner P, Chan S

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/29278858

Résumé

The IKZF family of transcription factors are essential regulators of lymphopoiesis. Ikaros, Helios, Aiolos and Eos function as transcriptional repressors and activators during T and B cell differentiation and in mature cell function, depending on the stage of development and/or cell type. Their potential mechanisms of action are varied. Ikaros family proteins partner with multiple complexes, including NuRD, PRC2 and transcription elongation factors, to modulate gene expression and the chromatin state. In humans, mutations in the IKZF genes are associated with B cell deficiency, leukemias and autoimmunity. In this review, we focus on the function of Ikaros family proteins in early T and B lymphocyte development, and discuss the molecular and physiological activities of this family.

Mots clés

Animals, Cell Differentiation, genetics, Cell Lineage, Gene Expression Regulation, Humans, Ikaros Transcription Factor, genetics, Lymphocyte Subsets, cytology, Lymphocytes, cytology, Lymphopoiesis, genetics, Mice, Multigene Family, Signal Transduction

Référence

Curr. Opin. Immunol.. 2017 Dec 23;51:14-23