Modulation of the functional association between the HIV-1 intasome and the nucleosome by histone amino-terminal tails.

Fiche publication

Date publication

novembre 2017

Journal

Retrovirology

Auteurs

Membres identifiés du Cancéropôle Est :
Dr RUFF Marc

Tous les auteurs :
Benleulmi MS, Matysiak J, Robert X, Miskey C, Mauro E, Lapaillerie D, Lesbats P, Chaignepain S, Henriquez DR, Calmels C, Oladosu O, Thierry E, Leon O, Lavigne M, Andreola ML, Delelis O, Ivics Z, Ruff M, Gouet P, Parissi V

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/29179726

Résumé

Stable insertion of the retroviral DNA genome into host chromatin requires the functional association between the intasome (integrase·viral DNA complex) and the nucleosome. The data from the literature suggest that direct protein-protein contacts between integrase and histones may be involved in anchoring the intasome to the nucleosome. Since histone tails are candidates for interactions with the incoming intasomes we have investigated whether they could participate in modulating the nucleosomal integration process.