Association between lung cancer somatic mutations and occupational exposure in never-smokers.

Date publication

octobre 2017

Journal

The European respiratory journal

Auteurs

Membres identifiés du Cancéropôle Est :
Dr COUDERT Bruno , Dr FOUCHER Pascal

Tous les auteurs :
Paris C, Do P, Mastroianni B, Dixmier A, Dumont P, Pichon E, Chouaid C, Coudert B, Foucher P, Fraboulet S, Locatelli-Sanchez M, Baize N, Dansin E, Moreau L, Vincent M, Missy P, Morin F, Moro-Sibilot D, Couraud S, ,

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/29074543

Résumé

Occupational exposure constitutes a common risk factor for lung cancer. We observed molecular alterations in 73% of never-smokers, 35% of men and 8% of women were exposed to at least one occupational carcinogen. We report herein associations between molecular patterns and occupational exposure.BioCAST was a cohort study of lung cancer in never-smokers that reported risk factor exposure and molecular patterns. Occupational exposure was assessed a validated 71-item questionnaire. Patients were categorised into groups that were unexposed and exposed to polycyclic aromatic hydrocarbons (PAH), asbestos, silica, diesel exhaust fumes (DEF), chrome and paints. Test results were recorded for and mutations, and alterations.Overall, 313 out of 384 patients included in BioCAST were analysed. Asbestos-exposed patients displayed a significantly lower rate of mutations (20% 44%, p=0.033), and a higher rate of mutations (18% 4%, p=0.084). alterations were not associated with any occupational carcinogens. The DEF-exposed patients were diagnosed with a mutation in 25% of all cases. Chrome-exposed patients exhibited enhanced and mutation frequency.Given its minimal effects in the subgroups, we conclude that occupational exposure slightly affects the molecular pattern of lung cancers in never-smokers. In particular, asbestos-exposed patients have a lower chance of mutations.

Mots clés

Adenocarcinoma, etiology, Aged, Aged, 80 and over, Asbestos, adverse effects, Biomarkers, Tumor, genetics, ErbB Receptors, genetics, Female, France, Gasoline, adverse effects, Humans, Logistic Models, Lung Neoplasms, etiology, Male, Middle Aged, Mutation, Occupational Exposure, adverse effects, Prospective Studies, Proto-Oncogene Proteins B-raf, genetics, Receptor, ErbB-2, genetics, Risk Factors, Smoking, epidemiology

Référence

Eur. Respir. J.. 2017 Oct;50(4):