Effectiveness of antibacterial prophylaxis in children with acute leukemia: A report from a single institution over a 20-year period.

Fiche publication

Date publication

octobre 2018

Journal

Archives de pediatrie : organe officiel de la Societe francaise de pediatrie

Auteurs

Membres identifiés du Cancéropôle Est :
Pr CHASTAGNER Pascal , Dr FOUYSSAC Fanny

Tous les auteurs :
Chastagner P, Michel D, Contet A, Lozniewski A, Hadou T, Schmitt C, Phulpin A, Fouyssac F, Mansuy L

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/30340941

Résumé

Infection is the major cause of treatment-related mortality in childhood acute leukemia, mainly due to bacterial translocation across the intestinal mucosa. Only a few studies have reported the impact of different antibacterial prophylaxis treatments on digestive tract flora and infection-related mortality.