[Hippocampus, brainstem and brain dose-volume constraints for fractionated 3-D radiotherapy and for stereotactic radiation therapy: Limits and perspectives].

Date publication

septembre 2017

Journal

Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique

Auteurs

Membres identifiés du Cancéropôle Est :
Pr NOEL Georges

Tous les auteurs :
Gérard M, Jumeau R, Pichon B, Biau J, Blais E, Horion J, Noël G

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/28893524

Résumé

Cerebral radiation-induced toxicities after radiotherapy (RT) of brain tumors are frequent. The protection of organs at risk (OAR) is crucial, especially for brain tumors, to preserve cognition in cancer survivors. Dose constraints of cerebral OAR used in conventional RT, radiosurgery (SRS) and stereotactic radiotherapy (SRT) are debated. In fact, they are based on historical cohorts or calculated with old mathematical models. Values of α/β ratio of cerebral OAR are also controversial leading to misestimate the equivalent dose in 2Gy fractions or the biological equivalent dose, especially during hypofractionated RT. Although recent progresses in medical imaging, the diagnosis of radionecrosis remains difficult. In this article, we propose a large review of dose constraints used for three major cerebral OAR: the brain stem, the hippocampus and the brain.

Mots clés

Brain, Brainstem, Conformational radiotherapy, Dose constraints, Doses de tolérance, Encéphale, Hippocampe, Hippocampus, Organ at risk, Organe à risque, Radionecrosis, Radionécrose, Radiothérapie conformationnelle, Radiothérapie stéréotaxique, Stereotactic radiation therapy, Tronc cérébral

Référence

Cancer Radiother. 2017 Sep;: