Fiche publication
Date publication
octobre 2017
Journal
Micromachines
Auteurs
Membres identifiés du Cancéropôle Est :
Dr LEBLOIS Thérèse
Tous les auteurs :
Azzopardi CL, Lacour V, Manceau JF, Barthès M, Bonnet D, Chollet F, Leblois T
Lien Pubmed
Résumé
Resonant biosensors are known for their high accuracy and high level of miniaturization. However, their fabrication costs prevent them from being used as disposable sensors and their effective commercial success will depend on their ability to be reused repeatedly. Accordingly, all the parts of the sensor in contact with the fluid need to tolerate the regenerative process which uses different chemicals (H₃PO₄, H₂SO₄ based baths) without degrading the characteristics of the sensor. In this paper, we propose a fluidic interface that can meet these requirements, and control the liquid flow uniformity at the surface of the vibrating area. We study different inlet and outlet channel configurations, estimating their performance using numerical simulations based on finite element method (FEM). The interfaces were fabricated using wet chemical etching on Si, which has all the desirable characteristics for a reusable biosensor circuit. Using a glass cover, we could observe the circulation of liquid near the active surface, and by using micro-particle image velocimetry (μPIV) on large surface area we could verify experimentally the effectiveness of the different designs and compare with simulation results.
Mots clés
biosensor, fluidic interface, micro-machining, microengineering, planar flow
Référence
Micromachines (Basel). 2017 Oct 14;8(10):
